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ノート
ノート73件のうち3件すべて表示
- Pushmi-pullyu: What’s an activated satellite cell to do? 2009年12月21日 15:55|コメント2件
- Heads or tail(ins)? Talin flips-out to promote integrin adhesion. 2009年11月24日 10:44|コメント1件
- Journeys through the Golgi – is Golgi research in a happy place? 2009年11月10日 7:24
Journal of Cell Biologyさん
Both the cargo and the clathrin adaptor protein can affect the size and turnover of clathrin coated pits. Uneven and mobile clusters of AP2 are evident within enlarged clathrin-coated structures when Dab2 and its receptor CD8/LDLR are over-expressed, although distribution of Dab2 remains uniform.
Read the full article... online at:
http://jcb.rupress.org/cgi/content/full/
Journal of Cell Biologyさん
People and Ideas – Isabelle Vernos: Motoring around the mitotic spindle
Lots of different motors are involved in organizing the mitotic spindle. “I don’t think anyone thought there could be so many motors in Xenopus,” says Isabelle Vernos, who uses cutting-edge microscopy to track assembly of the mitotic spindle in Xen...opus eggs. Vernos characterized the kinesin-like motors Xkid and Xklp1, which create the “polar ejection force”, positioning chromosomes at the metaphase plate, among other jobs. To find out more about Vernos’ molecular-motor guided tour of spindle biology, see “People and Ideas”, part of the March 8, 2010 issue of the JCB.
http://jcb.rupress.org/cgi/content/full/
Journal of Cell Biologyさん
REVIEW: The Golgi and the centrosome: Building a functional partnership.
In interphase cells, the Golgi (red) nestles up next to the centrosome (green), but it distances itself from this microtubule organizing center during mitosis. In the March 8, 2010 issue of the JCB, Christine Sϋtterlin and Antonio Colanzi review w...hat we know about the link between organization of the Golgi and cell cycle progression.
Review: http://jcb.rupress.org/cgi/content/full/
Journal of Cell Biologyさん Read a roundup of the latest issue highlights on the JCB blog...
jcb-biowrites.rupress.org
It's a little later than usual, but here's a roundup what you can find in the latest issue of the JCB... Our spectacular cover image shows the epithelial cells of a Drosophila embryo torn apart when they lack armadillo -...
Journal of Cell Biologyさん Listen to the latest Biobytes podcast
jcb.rupress.org
In the March 8th edition of biobytes, Luisa Iruela-Arispe (UCLA, Los Angeles, CA) explains how VEGF signaling depends on the growth factor's context (Chen et al., JCB); and Aaron DiAntonio (Washington University, St. ...
Journal of Cell Biologyさん
From the Archive: Ribosomes, or the particles of Palade
When George Palade noted a particulate component of the cytoplasm, he confirmed its presence using two different fixatives to avoid “the perennial and arduous question of artifact versus reality.”
Palade saw the structures were both on the ER and free in the cytop...lasm. But Palade realized that the “basophilic cytoplasm”, RNA-rich areas that stain with basic dyes, and “Nissl bodies” in neurons were one and the same. The correlation between rough ER and protein synthesis came later with correlative EM and biochemistry studies.
From the Archive: http://jcb.rupress.org/cgi/content/full/
Journal of Cell Biologyさん Cilium formation: Lessons from the past
jcb-biowrites.rupress.org
I recently attended a Keystone Symposium on Cilia, Signaling and Human Disease … Several of the talks showed EM images from a JCB paper published in 1962. This made me curious about the article and I decided to investigate.
Journal of Cell Biologyさん is very excited about its latest Facebook milestone: more than 1,000 fans! Thanks to all for signing on and helping to make the JCB fan page such a success.
Journal of Cell Biologyさん
In Focus – Centrosomes remember which way is up
Although Drosophila neuroblasts (stem cells found in larval brains) can divide more than 100 times, the orientation of the divisions remains constant. “The orientation of the stem cells doesn’t depend on the external environment,” says author Jens Januschke, “It’s generat...ed in a cell-autonomous manner.” To find out more about how microtubule-based memory helps orient dividing brain cells, see the paper and the accompanying “In Focus” article, which are both part of the March 8, 2010 issue of the JCB.
In Focus: http://jcb.rupress.org/cgi/content/full/
Article: http://jcb.rupress.org/cgi/content/full/
Journal of Cell Biologyさん
Reducing adherens junction components (such as Armadillo- Drosophila beta-catenin- shown here) or ablating actomyosin networks in individual cells causes tissue-wide tears during ventral furrow formation. The transcription factor twist stabilizes myosin II and promotes formation of radial actomyosin fibers that join u...p at cell-cell junctions, say Martin et al.
http://jcb.rupress.org/cgi/content/full/
Journal of Cell Biologyさん
Graham Warren: Gaining ground on the Golgi
Graham Warren has made it his life’s work to demystify the biology of the Golgi. To learn more about the rich trove of insights yielded by Warren’s studies of this essential organelle, see “People and Ideas” in the February 22, 2010 issue of the JCB.
http://jcb.rupress.org/cgi/content/full/
Journal of Cell Biologyさん
In Focus - Glycosphingolipids keep signaling in top-Notch condition
The lipids that surround cell surface proteins have a significant influence on the Notch signaling pathway, say Hamel et al. To learn more, see the paper and the accompanying “In Focus” article, which both appear in the February 22, 2010 issue of the ...JCB.
In Focus: http://jcb.rupress.org/cgi/content/full/
Article: http://jcb.rupress.org/cgi/content/full/
Journal of Cell Biologyさん New biosights: A microtubule-independent network of proteins called the spindle matrix is involved in assembling mitotic and meiotic spindles, but whether the matrix makes a mechanical contribution to spindle shape is unclear. Gatlin et al. manipulate spindles with microneedles to directly probe the mechanical properti...es of the spindle matrix. This biosights episode presents the paper by Gatlin et al. from the February 22, 2010 issue of The Journal of Cell Biology, and includes an interview with lead author Jay Gatlin. Produced by Eun Choi and Ben Short.
長さ:6:45
Journal of Cell Biologyさん New issue roundup...
jcb-biowrites.rupress.org
There's a new issue of the JCB out today - let's take a quick look at some of the highlights... Our cover story for this issue is Hamel et al.'s discovery that membrane glycosphingolipids modify the activity of the Notch...
